[Sar9] Substance P
CAS No. 77128-75-7
[Sar9] Substance P ( —— )
产品货号. M30560 CAS No. 77128-75-7
[Sar9]-Substance P is one of NK-1 receptor agonist. The action of SP on progesterone metabolism was mimicked by the rNK1-specific agonist [Sar-9,Met(O2)11]-SP.
纯度: >98% (HPLC)
规格 | 价格/人民币 | 库存 | 数量 |
100MG | 获取报价 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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100MG | 获取报价 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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生物学信息
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产品名称[Sar9] Substance P
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述[Sar9]-Substance P is one of NK-1 receptor agonist. The action of SP on progesterone metabolism was mimicked by the rNK1-specific agonist [Sar-9,Met(O2)11]-SP.
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产品描述[Sar9]-Substance P is one of NK-1 receptor agonist. The action of SP on progesterone metabolism was mimicked by the rNK1-specific agonist [Sar-9,Met(O2)11]-SP.
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同义词——
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通路GPCR/G Protein
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靶点Neurokinin Receptor
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受体Neurokinin (NK)-1 receptor
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研究领域——
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适应症——
化学信息
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CAS Number77128-75-7
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分子量1361.7
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分子式C64H100N18O13S
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纯度>98% (HPLC)
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溶解度——
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SMILES——
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化学全称Sequence:{Arg}{Pro}{Lys}{Pro}{Gln}{Gln}{Phe}{Phe}{SAR}{Leu}{Met}-NH2
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
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QWF
Tripeptide substance P (SP) antagonist (IC50 = 90 μM). Also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Inhibits SP-induced IgE-independent degranulation of mast cells in vitro. Inhibits compound 48/80-induced MRGPRX2 activation and scratching in mice in vivo.
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Hemokinin 1 (human)
Endogenous substance P homolog that is a selective agonist at the tachykinin NK1 receptor (IC50 values are 1.8, 370 and 480 nM for NK1, NK3 and NK2 receptors respectively). Has proliferative and antiapoptotic actions on B-cells in vitro and is antihypertensive in vivo.
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Neurokinin A(4-10)
Neurokinin A (4-10) is a tachykinin NK2 receptor agonist. A structure-activity study of the neurokinin A (NKA) fragment NKA(4-10) was performed to investigate the importance of amino acid residues for receptor efficacy, potency and affinity at the NK2 receptor in human colon circular muscle.